2021 season | |
| 23 January 2022: Bills at Chiefs 2021 Season Divisional Playoff | |
| 16 January 2022: Patriots at Bills 2021 Season Wildcard Playoff | |
| 09 January 2022: Jets at Bills Week 18 | |
| 02 January 2022: Falcons at Bills Week 17 | |
| 26 December 2021: Bills at Patriots Week 16 | |
| 19 December 2021: Panthers at Bills Week 15 | |
| 12 December 2021: Bills at Buccaneers Week 14 | |
| 06 December 2021: Patriots at Bills Week 13 | |
| 25 November 2021: Bills at Saints Week 12 | |
| 21 November 2021: Colts at Bills Week 11 | |
| 14 November 2021: Bills at Jets Week 10 | |
| 07 November 2021: Bills at Jaguars Week 9 | |
| 31 October 2021: Dolphins at Bills Week 8 | |
| 18 October 2021: Bills at Titans Week 6 | |
| 10 October 2021: Bills at Chiefs Week 5 | |
| 03 October 2021: Texans at Bills Week 4 | |
| 26 September 2021: WFT at Bills Week 3 | |
| 19 September 2021: Bills at Dolphins Week 2 | |
| 12 September 2021: Steelers at Bills Week 1 | |