2022 season | |
| 24 December 2022: Bills at Bears Week 16 | |
| 17 December 2022: Dolphins at Bills Week 15 | |
| 11 December 2022: Jets at Bills Week 14 | |
| 01 December 2022: Bills at Patriots Week 13 | |
| 24 November 2022: Bills at Lions Week 12 | |
| 20 November 2022: Browns at Bills Week 11 | |
| 16 October 2022: Bills at Chiefs Week 6 | |
| 09 October 2022: Steelers at Bills Week 5 | |
| 02 October 2022: Bills at Ravens Week 4 | |
| 25 September 2022: Bills at Dolphins Week 3 | |
| 19 September 2022: Titans at Bills Week 2 | |
| 08 September 2022: Bills at Rams Week 1 | |